Baytril Otic is a medicine for the treatment of otitis externa (inflammation of the external ear canal) in dogs. It contains the antibiotic enrofloxacin (0.5%) and silver sulfadiazine (1%), a type of antibacterial sulfa. This combination of ingredients is particularly effective against gram-negative bacteria, but is also effective against some fungal/yeast infections.

How To Use It

Note: This medicine should only be used under the guidance of your vet.

Usually, when treating susceptible ear infections you will administer between 5 and 15 drops every 12 hours (twice daily) for up to 14 days, shaking the bottle well before each use. Apply the drops to the affected lesions in the ear and into the ear canal and then gently massage the area to help with absorption.

A general dosage guideline is shown in the table below.

Weight of Dog

Drops To Use

Up to 35 lbs5 – 10 every 12 hours
Over 35 lbs10 – 15 every 12 hours

Remember, the exact dosage can vary on a number of factors so seek exact guidance from your vet before use.

Is It Safe?

Baytril Otic appears to be very safe for use in dogs. In studies into its safety, beagles were given up to 50 drops twice daily for 42 days. Redness around the treated area due to irritation was noted, but this resolved after use was discontinued. The medicine was also placed into the mouth to test for safety in case of accidental ingestion (for example, if a dog managed to lick some of the emulsion), and this did not cause any problems.

Side effects are also rare.

Because enrofloxacin is one of the active ingredients, tell the vet if your dog is at risk of seizures, or who are still in the growing phase. The growing phase tends to be the first eight months of life for small and medium breeds, the first twelve months for large breeds and the first eighteen months for giant breeds.

What Is It Used For?

As mentioned, the solution may be effective against certain fungal/yeast infections, but is most often used to treat ear infection caused by:

  • Aeromonas hydrophila
  • Aspergillus spp.
  • Candida albicans
  • Enterobacter spp.
  • Klebsiella pneumoniae
  • Malassezia pachydermatis
  • Pseudomonas aeruginosa
  • Proteus mirabilis
  • Staphylococcus spp. (coagulase-positive)
  • Streptococcus spp.


Side Effects

Side effects in healthy dogs are not expected but a hypersensitivity to either substance contained in the medicine could cause inflammation of the ear canal. Using too much or extending treatment beyond the recommended 14 days may result in redness around the treated area.

If your dog’s hearing appears to be affected or if he seems to have lost his balance, discontinue use and seek advice from your vet.

Bayer (manufacturer)
Plumb’s Veterinary Drug Handbook (sixth edition)