The information on this page outlines the contraindications and drug interacts of ketoconazole as it applies to dogs.
 

Contraindications

 
Dogs with the following medical conditions may not be suitable for treatment with ketconazole:

Liver disease, thrombocytopeni. It can still be used in patients with Addison’s disease but they will need increased glucocorticoid supplementation.

Pregnancy: Use in pregnant dogs is currently not advised as it could be toxic to embryos.
 

Substances

 
Ketoconazole interacts with a large number of known substances:

Alfentanil, alfuzosin, alprazolam, amiodarone, anagrelide, apixaban, arsenic (trioxide), astemizole, atorvastatin, avanafil, axitinib, bedaquiline, bepridil, bosutinib, ceritinib, cerivastatin, cisapride, citalopram, clopidogrel, clozapine, colchicine, conivaptan, crizotinib, cyclosporine, dabigatran, darifenacin, dasatinib, dihydroergotamine, disopyramide, docetaxel, dofetilide, dolasetron, dronedarone, droperidol, eletriptan, eliglustat, eplerenone, ergonovine, ergotamine, erythromycin, escitalopram, everolimus, felodipine, fentanyl, gatifloxacin, grepafloxacin, halofantrine, haloperidol, ibrutinib, ibutilide, iloperidone, irinotecan, ivacaftor, leflunomide, levomethadyl acetate, lomitapide, lovastatin, lurasidone, macitentan, maraviroc, mefloquine, mesoridazine, methadone, methylergonovine, methysergide, midazolam, mifepristone, mipomersen, moxifloxacin, nilotinib, nimodipine, nisoldipine, pasireotide, pazopanib, pimozide, quetiapine, quinidine, ranolazine, riociguat, rivaroxaban, ruxolitinib, salmeterol, sildenafil, silodosin, simeprevir, simvastatin, sirolimus, sotalol, sparfloxacin, suvorexant, tacrolimus, tamsulosin, terfenadine, teriflunomide, thioridazine, ticagrelor, tofacitinib, tolvaptan, toremifene, tretinoin, triazolam, vandetanib, vardenafil, vemurafenib, vinblastine, vincristine, vinorelbine, vorapaxar, ziprasidone.
 

I’ve Given Ketoconazole To An Unsuitable Dog!

 
If you think you’ve administered ketoconazole to an unsuitable dog you should ring your vet for advice immediately. Side effects resulting from some drug interactions are uncommon, for example abnormal heart rhythm resulting from the combination of ketoconazole and alprazolam is considered to be rare. If your pet suffers any serious reactions following the use of ketoconazole seek emergency care.

[sc:Bottom]