Naproxen is not considered very safe for use in dogs due to the high risk of adverse effects and overdose. Because of this, it is not often used unless all other alternatives have ben exhausted. You will find more information about the contraindications and drug interactions of naproxen below.


Dogs with the following conditions are contraindicated for treatment with naproxen:

Gastrointestinal ulcers, diseases of the kidney, liver or blood, heart failure. It should also not be given to dogs who have reacted poorly to the substance in the past. You should also notify the vet prior to treatment if your dog has suffered a bad reaction to any other NSAIDs in the past.

Drug Interactions

Always tell the vet about any other substances your dog is taking prior to treatment. The following drugs are known to interact with naproxen:

Adefovir, anisindione, apixaban, ardeparin, cabozantinib, cidofovir, dabigatran, dalteparin, danaparoid, dasatinib, deferasirox, desirudin, dicumarol, enoxaparin, fondaparinux, ibritumomab, ibrutinib, ketorolac, leflunomide, lomitapide, methotrexate, mipomersen, omacetaxine, ponatinib, prasugrel, ramucirumab, regorafenib, rivaroxaban, sirolimus, sodium biphosphate, tacrolimus, tenofovir, teriflunomide, tinzaparin, tositumomab, warfarin.

I Just Gave Naproxen To An Unsuitable Dog!

Because of the potentially dangerous side effects associated with naproxen use in dogs it’s important to contact a vet immediately if you think you’ve given it to an unsuitable pet. Follow your vet’s instructions carefully and look out for signs of a bad reaction such as vomiting, diarrhea and an irregular heartbeat.