Tramadol is often safe for healthy dogs who aren’t taking other medication, but there are many known drug interactions and many contraindications for its use. The following information will help you determine your dog’s tramadol suitability.

Medical Conditions

Check with a vet if any of the following applies to your dog:

Depression, pregnancy, seizures, head injuries, poor lung function, kidney problems, liver problems, nervous system problems, serotonin syndrome, infections relating to the brain and spinal cord.


Mixing tramadol with any of the following substances could result in negative side effects and interactions:

Aldesleukin, alfentanil, almotriptan, alvimopan, amantadine, aminophylline, amitriptyline, amoxapine, amphetamine, asenapine, benzphetamine, bethanechol, buprenorphine, bupropion, butorphanol, chloroquine, chlorpromazine, cinoxacin, ciprofloxacin, citalopram, clomipramine, clozapine, codeine, cyclobenzaprine, cycloserine, cyclosporine, dalfampridine, desipramine, desvenlafaxine, dezocine, diethylpropion, donepezil, doxapram, doxepin, eletriptan, enoxacin, enzalutamide, ephedrine, ertapenem, escitalopram, fenfluramine, fentanyl, fluoxetine, fluphenazine, fluvoxamine, foscarnet, frovatriptan, furazolidone, galantamine, gatifloxacin, gemifloxacin, grepafloxacin, haloperidol, hydrocodone, hydromorphone, iloperidone, imipramine, interferon, iohexol, iopamidol, isocarboxazid, levofloxacin, levomethadyl acetate, levomilnacipran, levorphanol, lidocaine, lindane topical, linezolid, lisdexamfetamine, lithium, lomefloxacin, lorcaserin, loxapine, lurasidone, ma huang, maprotiline, mazindol, mefloquine, meperidine, meropenem, mesoridazine, methadone, methamphetamine, methdilazine, methotrimeprazine, methylene blue, methylphenidate, metoclopramide, metrizamide, mexiletine, milnacipran, mirtazapine, molindone, morphine, moxifloxacin, muromonab-cd3, nalbuphine, nalidixic acid, naratriptan, nefazodone, nelarabine, neostigmine, norfloxacin, nortriptyline, ofloxacin, olanzapine, oxamniquine, oxtriphylline, oxycodone, oxymorphone, paliperidone, paroxetine, peginterferon, pemoline, pentazocine, perphenazine, phendimetrazine, phenelzine, phentermine, phenylpropanolamine, physostigmine, pimozide, piperazine, preventic tick collar, procarbazine, prochlorperazine, promazine, promethazine, propiomazine, propoxyphene, protriptyline, quetiapine, rasagiline, remifentanil, rimantadine, risperidone, rivastigmine, rizatriptan, selegiline, sertraline, sibutramine, sparfloxacin, st. john’s wort, sufentanil, sumatriptan, tacrine, tapentadol, theophylline, thiethylperazine, thioridazine, thiothixene, tranylcypromine, trazodone, trifluoperazine, triflupromazine, trimeprazine, trimipramine, trovafloxacin, tryptophan, venlafaxine, vilazodone, vortioxetine, ziprasidone, zolmitriptan.

Note: Administering tramadol with MAOIs (selegiline, preventic tick collar) or SSRIs (Prozac, citalopram) can lead to a condition known as “serotonin syndrome”. This is a rare but very serious problem often overlooked during diagnosis with symptoms such as trembling, confusion, problems walking, vomiting, diarrhea, racing heart rate, rapid breathing and hyperthermia. If left untreated, this condition could lead to coma and even death. Contact a vet as soon as you suspect your dog has developed serotonin syndrome.

I Just Gave Tramadol To An Unsuitable Dog!

If you think you’ve given tramadol to a dog who’s not suitable you should call the vet for advice and watch your pet very closely for the next 24 hours. You may be asked to bring your dog down to the vet’s practice or animal hospital for a check-over. Some interactions are very dangerous and in serious cases hospitalization may be required.